Memory andolfactory sensitivity were also impaired in A1 AR-/- mice with signs of anxiety.Immunofluo-rescence staining with GFAP, IBA1 revealed astrogliosis in the AR knock out mice.Western blot assay quantification of MOG revealed a significant decrease in A1 AR-/- but anincrease in A2A AR-/- mice. This evidence concerns the gene AR and Anxiety.