In an analysis of covariance including age, sex, body mass index, glycemiccontrol (HbA1c), depression, and antidepressant use, the 12,13 diol/epoxide ratio wasassociated with BDNF (F=2.674, p=0.012) but this relationship was specific to those withoutdepression (depression×12,13 ratio interaction F=4.586, p=0.035). The gene discussed is BDNF; the disease is depressive symptom measurement.