Taken together, our datasuggest for the first time that IFNg signaling in astrocytes upregulates the iP withregional specificity and has a novel role in contributing to CNS homeostasis by reducing ROSand degrading damaged poly-ubiquitinated proteins during chronic neuroinflammation.Understanding the role of the astrocyte iP and further dissecting the protective functionsof IFNg during chronic neuroinflammation may lead to development of novel targets fortreatment of progressive MS. The gene discussed is IFNG; the disease is myeloid sarcoma.