Th1 cells highly express thechemokine receptor CXCR3, and its ligand CXCL10 is upregulated in the CNS in MS and EAE.Here, we have tested the hypothesis that CXCR3 promotes migration of T cells across the BBBdependent on endothelial Cav-1. This evidence concerns the gene CXCR3 and myeloid sarcoma.