IFNG and experimental autoimmune encephalomyelitis: We confirmed that iP expression wasstimulated by IFNg in regional primary adult human astrocytes and that specific inhibitionof the iP using ONX 0914 following IFNg stimulation resulted in increased ROS, anaccumulation of oxidatively damaged proteins, and enhanced caspase-3- mediated cell death.In a murine model of chronic MS, experimental autoimmune encephalomyelitis (EAE), ONX 0914treatment led to exacerbated disease and increased lesion size, astrocyte oxidative stressand poly-ubiquitinated protein accumulation.