All proteins in this family have been implicated in various clinical conditions; prolyl endopeptidase (PREP; OMIM 600400), oligopeptidase B (OpdB) (role in host cell invasion by Trypanosoma cruzi, Chagas disease),11 acylaminoacyl‐peptidase (APEH; OMIM 102645), and dipeptidase IV (DPPIV; OMIM 102720). This evidence concerns the gene PREP and Chagas disease.