We then performed immunofluorescence staining and investigated that the levels of autophagy (Beclin‐1, LC3B), apoptosis (cleaved caspase‐3) and p‐AMPK in osteoblasts (osterix) were significantly higher in SONFH than in osteoarthritis patients (Figure 1C). The gene discussed is BECN1; the disease is osteoarthritis.