B2M and cancer: Differential expression analysis of PRAME overexpressing and control cancer cells (p < 0.05, fold enrichment >50) identified the top 10 upregulated genes to include AICDA, IDO1, MYD88, IL‐15, CXCL1, GZMB, CXCR3, CCR, GBP1 and CXCL10, whereas the top 10 downregulated genes include TNFSF10, B2M, IRF1, CXCR5, CSF1, FASLG, MIF, CXCL2, IL4 and MICA (Figure 5A).