In LADA patients, TCF7L2‐T2D common variants rs12255372 and rs7903146 are associated only with low Glutamic Acid Decarboxylase Antibody (GADA) titers, showing heterogeneous genetic and clinical characteristics in LADA patients according to GADA titers; the authors hypothesize that the TCF7L2‐risk alleles predispose to lower insulin secretion in these patients (Zampetti et al., 2010). This evidence concerns the gene INS and type 2 diabetes mellitus.