Furthermore, TCF7L2 SNPs were tested in PCOS subjects for association with PCOS quantitative traits (e.g., BMI, total testosterone, dehydroepiandrosterone sulfate [DHEA‐S], sex hormone‐binding globulin [SHBG], proinsulin:insulin ratio [a marker of pancreatic β‐cell dysfunction]). This evidence concerns the gene TCF7L2 and polycystic ovary syndrome.