TCF7L2 and obesity due to melanocortin 4 receptor deficiency: Obese carriers of the TCF7L2‐rs7903146 TT‐genotype have 2.62‐times higher odds of T2D compared to those with other genotypes, and this relationship appears even stronger after adjusting for obesity‐onset age, male gender, dyslipidemia, and lower serum total adiponectin (Wrzosek et al., 2019).