By integrating RNA‐seq data, functional in vitro experiments, and xenograft animal model, Cut et al. discovered that EphA2‐SE plays an oncogenic role and contributes to tumor progression in several tumors, as it recruits FOSL2 and TCF7L2 to drive the expression of the oncogene EphA2 (Cui et al., 2021). This evidence concerns the gene TCF7L2 and neoplasm.