6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), a bifunctional glycolytic enzyme with two homodimer subunits that own two functional domains and, respectively, play the dual functions of kinase and phosphatase, respectively [11,12], can accelerate the process of glycolysis to provide energy and opportunities for the tumor cells to reproduce and invade. The gene discussed is PFKFB3; the disease is neoplasm.