Early insight into such coordinated tumor-intrinsic programs driven by Ras-p53 cooperativity came from an elegant study by McMurray and colleagues in which murine colon cells containing individual or combined mutants of p53 (p53R175H) or activated H-Ras (RasG12V) were profiled by microarray analysis to delineate a set of gene transcripts—encompassing a broad range of functional annotations such as signal transduction, metabolism, cell adhesion, etc.—that are synergistically regulated by Ras-p53 cooperative signaling [23]. This evidence concerns the gene TP53 and neoplasm.