Based on the data presented here, it would be worthwhile to consider the novel peptides designed here for Ags overexpressed in MM (MUC1, SLAMF7, BCMA, FcRH5, RHAMM) or cancer testis Ags (CT45, NY-ESO-1) and SEPTIN9 as potential targets for MM immunotherapy. This evidence concerns the gene MUC1 and Miyoshi myopathy.