Daratumumab (DARA) is a human IgG1 monoclonal antibody that targets Cluster of Differentiation 38 (CD38), inducing tumor cell death through multiple mechanisms, including antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity, and antibody-dependent cellular phagocytosis (ADCP) [1]. The gene discussed is CD38; the disease is neoplasm.