Based on the involvement of CD molecules in a given network, top disease/functions in 3D cultured cells (Supplementary Table 16A) include: CD146 (MCAM)-cancer and angiogenesis, network #2, CD99-cellular growth and proliferation, network #6, CD280 (MRC2)-organization and proliferation, network #7, CD87 (PLAUR) and CD109-cancer, network #8, CD91 (LRP1)-organization and angiogenesis, network #10 and CD239 (BCAM)-connective tissue disorder and angiogenesis, network #17 (Supplementary Figures 2–7). The gene discussed is PLAUR; the disease is cancer.