Also interesting was the p53-dependent, CPT-11-specific regulation of transcripts including TLR3, a toll-like receptor known to promote anti-cancer immunity through activation of type I IFN; FDXR, or ferredoxin reductase, whose interaction with p53 is critical for tumor suppression via iron homeostasis; and DRAM1, a p53 target gene that modulates autophagy and apoptosis [37–39] (Figure 5B). The gene discussed is FDXR; the disease is cancer.