Here, we describe a database of transcriptomic and cytokine responses of HCT116 and HCT116 p53−/− cells to clinically relevant chemotherapeutics used to treat CRC including 5-FU, CPT-11, oxaliplatin, and cisplatin (not used to treat CRC but included for comparison to oxaliplatin). Here, TP53 is linked to colorectal carcinoma.