In line with our findings, SF3B2 mRNA expression also showed a positive correlation with RNF6 mRNA expression in CRC samples from our cohort (R = 0.411, P < 0.001), TCGA cohort (R = 0.224, P < 0.001) (Fig. 3B), and in human cancer cell lines encyclopedia (CCLE, https://depmap.org/) (R = 0.142, P < 0.0001) (Supplementary Fig. 2G), implying a positive association between RNF6 and SF3B2 expression in human CRC. This evidence concerns the gene RNF6 and cancer.