BRAF and melanoma: In line with the mutual exclusivity of BRAF and NRAS mutations in melanoma [42], we found that high IER2 expression is associated with wild-type BRAF and mutated NRAS. Importantly, high IER2 expression was almost exclusively associated with wild-type p53 status (Fig. 2b), consistent with our findings that p53 levels are increased in melanoma cells upon sustained IER2 expression (see below).