Stabilization of these onco-proteins during CPPD exposure indeed depends on USP28, as the lung cancer cell line SK-MES1 (SCC), which is mutant for USP28 and expresses low levels thereof, showed some degree of c-JUN or c-MYC destabilization after CPPD treatment (Fig. S1F–H). The gene discussed is USP28; the disease is lung carcinoma.