Toll like receptors TLR1 (p = 0.0431), TLR3 (p = 0.00356), the myeloid TLR6 (p = 0.026), TLR7 (p = 0.050), TLR8 (p = 0.079), and the TLR downstream and anti-viral regulatory factor 3 IRF3 (p = 0.018) are significantly reduced in MetS. This evidence concerns the gene TLR1 and metabolic syndrome.