The RNA-seq data from four of the MetS and four of the LD pigs (Fig. 1a) demonstrate a significant increase in the arachidonic acid (AA) pathway related phospholipase A2, PLA2G4A (p = 0.0224) and phospholipase beta, PLCB4 (p = 0.0092) that have the potential to supply multiple phospholipid-derived inflammatory metabolites within the cardiac endothelium; COX-1 (p = 0.019), COX-2 (p = 0.042), PTGES2 (p = 0.022) together with the PTGER2 receptor (p = 0.026), the thromboxane synthase, TBXAS1 (p = 0.075), as well as the xanthine dehydrogenase, XDH2/XO (p = 0.0044). The gene discussed is XDH; the disease is metabolic syndrome.