A preliminary study engineered a low-density lipoprotein nanoparticle reconstituted with the natural omega-3 PUFA, docosahexaenoic acid (LDL-DHA), and found that this nanoparticle promoted tumor suppression through triggering lipid peroxidation and ferroptosis via suppressing GPx4 activity and disturbing the balance of redox couples in HCC [98]. The gene discussed is GPX4; the disease is neoplasm.