We successfully detected the activated STAT3 pathway and upregulated EMT markers in GC cells by coculturing them with exosomes from OV circUBE2Q2 GC cells (OV exosomes) for 72 h compared with coculturing with exosomes from control GC cells (NC exosomes) (Fig. 7F and Supplementary Fig. 5E). This evidence concerns the gene STAT3 and gastric cancer.