Robust expression of both IL-6 (Supplementary Fig. 9A, B) and IFN-γ (Supplementary Fig. 9C, D) was detectable in the retina of untreated 3xTg-AD mice, while treatment with the anti-TNFSF10 antibody resulted in blunted expression of both inflammatory markers. This evidence concerns the gene IFNG and Alzheimer disease.