Western blot analysis revealed that while both TNFSF10 and its death receptor TNFRSF10B were highly expressed in the retinas of untreated 3xTg-AD mice, their expression was significantly attenuated following treatment with an anti-TNFSF10 antibody (Fig. 5A, B). The gene discussed is TNFRSF10B; the disease is Alzheimer disease.