The prominent role of TNFSF10 in Aβ-related neurodegeneration has been already demonstrated in different studies showing that neutralization of TNFSF10 pathway in an in vitro model of AD protects human neuronal cell line from Aβ−neurotoxicity [23]; as well as in the triple transgenic mouse model of AD (3xTg-AD) where it exerts a beneficial effect on central and peripheral AD-related inflammatory/immune response and disease outcome [27, 28]. Here, TNFSF10 is linked to Alzheimer disease.