While the expression of TNFRSF10B receptor was significantly reduced in the retinal RPE and OPL layers the expression of TNFSF10 was significantly blunted only in the retinal RPE layer of anti-TNFSF10 treated 3xTg-AD mice (Fig. 5C, D, Supplementary Fig. 2). Here, TNFSF10 is linked to Alzheimer disease.