Since it is known that TNFSF10 and its death receptor TNFRSF10B were specifically upregulated in the brain of 3xTg-AD mice [27], and given that the retina is regarded as a developmental outgrowth of the brain, we explored the role of both mediators in the retinas of 3xTg-AD mice treated chronically with an anti-TNFSF10 antibody. Here, TNFRSF10B is linked to Alzheimer disease.