For BCSC-immune cell cross-talk, LGALS1-PTPRC, NECTIN2-CD96, and NECTIN2/4-TIGIT are found to hamper immunity against breast cancer; by expressing TIMP-1, BCSC promotes epithelial-mesenchymal transition (EMT) by interacting with CD63 in epithelial cells [15–19]. The gene discussed is NECTIN2; the disease is breast carcinoma.