Each meta-program corresponded to a gene set with internal similarity or relativity, including energy metabolism (meta-program 1; CST3, CXCL14, COX6C...), cancer-related signaling pathways (meta-program 3; GSTP1, EMP1, TIMP-1...), immune activation and response (meta-program 5; LGALS3, PERP, and EMP1), lymphocyte activation (meta-program 7; CXCR4, CD3D, SRGN...), T-cell activation and DNA repair (meta-program 9; RICTOR, GZMK, IFI16...). The gene discussed is CD3D; the disease is cancer.