Interestingly, the patients with SLE with higher variant frequency (>2.7%) of GLK 3′-UTR (T635C) somatic variant showed a higher mean value of SLE disease activity index (SLEDAI), although statistically insignificant, compared with that of patients with SLE with lower variant frequency (<2.7%) (figure 3A). This evidence concerns the gene MAP4K3 and systemic lupus erythematosus.