Somatic mutation accumulation is associated with ageing due to the increase of clonal haematopoiesis25 26; therefore, the increased frequencies of GLK 3′-UTR (T635C) in Cohort #2 patients with SLE (with older age than Cohort #1) may be due to clonal haematopoiesis increasing with age. Here, MAP4K3 is linked to systemic lupus erythematosus.