In addition, higher frequencies (>2.7%) of GLK 3′-UTR (T635C) somatic variant in Cohort #1 were not associated with the development of rashes, oral ulcer, arthritis, serositis, neuropsychiatric, nephritis, as well as the treatment with cyclophosphamide (Endoxan), mycophenolate mofetil, cyclosporine or azathioprine (online supplemental table S4). This evidence concerns the gene MAP4K3 and arthritic joint disease.