MAP4K3 and systemic lupus erythematosus: To validate the abovementioned GLK gene variants in patients with SLE, we further recruited the second cohort containing 80 patients with sporadic SLE and 87 non-familial HCs from a different hospital (Kaohsiung Medical University Hospital; figure 1A, right panel and online supplemental table S3) located in another city, Kaohsiung City, in southern Taiwan.