MAP4K3 and systemic lupus erythematosus: At least one third of patients with SLE show a high frequency of GLK overexpressing T cells,13 while 39% (71 of 181) of patients with SLE have (A410T) germline variant/SNP, (K650R) germline variant/SNP, (A579T) germline variant, 3′-UTR (A644C) germline variant or 3′-UTR (T635C) somatic variant of GLK.