The meta-analysis did not show any significant changes in CSF NSE levels in PD/PDD/DLB (Hedges’ g = 0.343, 95% CI −0.027 to 0.713, p = 0.0694), although the data exhibited very high heterogeneity (Q = 48.85, df = 7, I2 = 81.58%, p < 0.0001). This evidence concerns the gene ENO2 and Lewy body dementia.