We identified rs72814833, which is closely correlated with rs17415557 (R2 = 0.99) and a 697 base pair upstream (5′) variant of BMI1, as significantly associated with CSF Aβ1-42 levels, cognitive performance at baseline, and rates of cognitive decline, which was replicated in ROSMAP, as expected due to the strong correlation between rs72814833 and rs17415557 (Supplementary table 1). This evidence concerns the gene BMI1 and Mental deterioration.