AGPS and Mental deterioration: Participants with minor alleles of BMI1 rs17415557 had slower cognitive decline over time compared to those with no minor alleles, for ADAS-cog13 (a higher score indicating poor cognitive function) in ADNI, β (SE) = − 0.035 (0.016) and p = 0.024; for a global composite measure of cognitive function (a lower score indicating poor cognitive function) in ROS/MAP, β (SE) = 0.024 (0.010) and p = 0.020.