Although little is known about the effect on sex in the association between air pollutants and osteoporosis, the reason for the difference between males and females is attributable to decreased estrogen level due to air pollutants can cause bone loss by upregulation of receptor activator of nuclear factor kappa-B ligand (RANKL), osteoblast proliferation, or osteoprotegerin production [21]. Here, TNFRSF11B is linked to osteoporosis.