Both function and pathway enrichment analyses highlighted the hypoxia and oxygen metabolism processes, such as “HIF-1 signaling pathway,” “response to oxidative stress,” “reactive oxygen species metabolic process,” “oxidation-reduction process,” “response to oxygen levels,” “oxidoreductase activity” and “organic hydroxy compound metabolic process.” Studies have found that hypoxia is a poor prognostic factor that regulates the tumor microenvironment. This evidence concerns the gene HIF1A and neoplasm.