While the mechanism of DHHC5 function in NSCLC is still unknown it is possible to compare the effect of ablating DHHC20 with DHHC5 in a large dataset from human NSCLC cell lines in the Cancer Dependency Map (DepMap) database to correlate the dependence of the cell growth effect with expression or mutation of EGFR signalling components [45]. The gene discussed is EGFR; the disease is cancer.