DHHC20-deficient NCI-H23 cells displayed reduced cell proliferation decreased AKT (T308) and GSK3β (S9) inhibitory phosphorylation leading to Myc phosphorylation and proteosomal degradation of Myc protein, suggesting that PI3K–AKT signalling, an EGFR downstream pathway parallel to the MAPK pathway, might play a role in the regulation of palmitoylation-dependent tumour growth. The gene discussed is ZDHHC20; the disease is neoplasm.