PDK4 and infection: Finally, we showed that chronic intraperitoneal injection of the PDK4 inhibitor DCA (100 mg per kg body weight per day; 0.25 μl h-1) starting 130 days after infection and before the onset of clinical signs (140 days) delayed mortality in Fk6-mice of 14 ± 3 days compared to untreated infected mice (178.5 ± 3.5 days vs. 164.5 ± 2.0 days, n = 10, p < 0.05, Fig 6A) with no overt sign of DCA toxicity.