Our results also revealed in Table 3 a significant reduction in the mean values of protein expression of RANKL and OPG and the gene expression of MMP-9 in CARV treated osteoporosis group and alendronate treated group when compared with untreated osteoporotic group, with no significant variations in RANKL/OPG ratios among all groups. The gene discussed is TNFSF11; the disease is osteoporosis.