A major conclusion of the The Cancer Genome Atlas (TCGA) analysis of kidney cancer was a metabolic shift in aggressive tumors marked by the downregulation of genes encoding enzymes of the TCA cycle, including FH; aconitase 2 (ACO2); succinate-CoA ligase, α subunit (SUCLG1); and oxoglutarate dehydrogenase (OGDH) (11). This evidence concerns the gene ACO2 and kidney cancer.