Activation of trypsin is normally catalyzedby enteropeptidase in the duodenum and serves as a the master regulatorystep in digestive enzyme activation, since trypsin is the common activatorof all other pancreatic zymogens.66 Prematureautoactivation of trypsin in the pancreas can cause a runaway activationcascade, leading to tissue damage, inflammation, and pancreatitis.66 Thus, BPTI and other potent pancreatic trypsininhibitors have evolved to regulate this key digestive enzyme. Here, TMPRSS15 is linked to pancreatitis.