DVL2 and neoplasm: [8] In addition, DVL2 expression level is tightly associated with Wnt activity and tumor progression.[26, 27] Trim56 is a E3 ubiquitin ligase and has been reported to target various proteins as well as regulate tumor progression.[27] Therefore, we hypothesize that cytoplasmic NEAT1_1 associates with DVL2 and Trim56, resulting in degradation of DVL2 and suppression of Wnt activity.