NPPB and heart failure: A randomised study presented by Taborsky et al., showed that RDN in patients with more advanced heart failure (mean LVEF was 25%, N = 51) resulted in significant improvements in LVEF, left ventricular end-systolic diameter (LVESD) and LVEDD as well as in NT-pro-BNP while no change was seen in patients with OMT alone [17].