INS and diabetes mellitus: In this context, a low-fat (LF) diet or a Mediterranean (MED) diet have been put forward as reasonable ways to delay T2DM development [6, 7]: the MED diet, rich in olive oil, seems to provide cardiovascular benefits and increase insulin sensitivity [7] and the LF diet contains < 30% energy from total fat and is recommended by the American Diabetes Association (ADA) [8].