At the same time in vitro studies of exogenous omentin-1 expression proved the cardioprotective functions of omentin-1: omentin-1 improved insulin sensitivity and anti-inflammatory activity of cultured EAT and SAT tissue samples of patients with cardiovascular disease and reduced atherosclerotic plaque formation in an ApoE-deficient animal model of atherosclerosis (Hiramatsu-Ito et al., 2016; Fernández-Trasancos et al., 2017). This evidence concerns the gene INS and atherosclerosis.