SOAT1 and Huntington disease: To determine if the FOXF2, OLIG2, and STAT pathways are key for human development of MSNs and represent useful TFs for disease modeling of MSN subtypes, we expressed the TFs alone or in combination in NSCs derived from HD patient-induced pluripotent stem cells (Figure 8; An et al., 2012; Naphade et al., 2017; Ring et al., 2015; Voisin et al., 2020; Zhang et al., 2010).