Despite brain tissues not displaying the highest CETP expression levels, CETP that is synthesized and secreted in the brain could play an important role in the transport and the redistribution of lipids within the central nervous system (Albers et al., 1992; Yamada et al., 1995) and has been associated with Alzheimer’s disease risk (Murphy et al., 2012; Oestereich et al., 2020). This evidence concerns the gene CETP and Alzheimer disease.