In our study, we revealed that hypoxia‐induced HIF‐1α could block ferroptosis and promote HCC survival via METTL14/YTHDF2 pathway, suggesting that targeting HIF‐1α/METTL14/YTHDF2 signal axis might have a synergistic effect to HCC interventional treatment. The gene discussed is YTHDF2; the disease is hepatocellular carcinoma.