METTL14 and hepatocellular carcinoma: In this study, by utterly investigating the alteration of METTL14 under hypoxia and the function of upregulated METTL14 in HCC pathogenesis, we found that METTL14 controlled ferroptosis by inducing ROS release and negatively regulating SLC7A11 expression via triggering m6A methylation at 5‘UTR of SLC7A11 mRNA.