As Figure 6A,B shown, under the hypoxic environment, wide‐type METTL14 but not the METTL14‐R298P mutant strongly inhibited SLC7A11 expression, while overexpression of SLC7A11 effectively abolished the downregulation of SLC7A11 induced by METTL14 in both HCC cell lines. Here, SLC7A11 is linked to hepatocellular carcinoma.