In this study, we did observe that silence of SCL7A11, a key member of ferroptosis signalling pathway, strongly upregulated E‐cadherin and downregulates N‐cadherin and Vimentin at both mRNA and protein levels, which provided a reasonable evidence that silence of SLC7A11 might inhibit migration of HCC cells. This evidence concerns the gene CDH1 and hepatocellular carcinoma.