SPNS3 and acute myeloid leukemia: In general, SPNS3 expression significantly influenced both EFS (P = 0.003, hazard ratio (HR) = 2.416; Figure 2(a)) and OS (P = 0.008, HR = 2.114; Figure 2(b)) of AML in the TARGET database and OS in TCGA database (P = 0.027, HR = 1.629; Figure 2(c)), and in PrognoScan database (P = 0.011, HR = 1.400) (Figure 2(d)).