The findings of our study were confirmed by subsequent post-mortem studies from other groups; Kantarci et al. [21] revealed that Braak NFT staging of HPτ was associated with ante-mortem DTI alterations in parietal white matter and medial-temporal lobe connections, and Alosco et al.[1] revealed ante-mortem WMH volume increased the odds of having a higher degree of AD-related pathology at autopsy. This evidence concerns the gene MRS2 and Alzheimer disease.