We investigated whether cerebrovascular pathologies, i.e., SVD (SI) and CAA, and cortical AD pathologies, i.e., HPτ (AT8-IR) or Aβ (4G8-IR) were associated with white matter pathological changes, i.e., WML severity (WMLA), axonal density (BiA), and myelin loss (LFB-IOD). The gene discussed is MRS2; the disease is Alzheimer disease.