Following on, numerous neuroimaging and neuropathological studies [1, 21, 25, 29, 30, 48] have suggested that WMH in the medial-temporal lobe and posterior regions of the brain can also occur as a result of degenerative white matter changes attributed to the deposition of cortical AD pathology, i.e., hyperphosphorylated tau (HPτ) and Aβ. Here, MRS2 is linked to Alzheimer disease.