In the field of bone metabolism, studies reported that the SNP located in exon 18 of the low-density lipoprotein receptor-related protein 5 (LRP5, Wnt coreceptor) gene, caused due to an amino acid change (3989C>T, A1330V), is associated with osteoporosis among patients in Japan, Europe, America, and South America9–18. Here, LRP5 is linked to osteoporosis.