We found that patients requiring hemodynamic support due to the vasoplegia of heart failure during COVID-19 demonstrated depressed levels of KLRD1, CXCL13, MCP-3, CXCL11, MUC-16, PD-1L, IL-18, IL-10, MCP-1, IL-16, IL-12RB1, CCL3, LAMP3, CASP8, CXCL10, Gal-9, and CCL-23 in urine (Fig. 5A). Here, CASP8 is linked to heart failure.