The gene with the most significant difference between CD64+ CD206+ and CD64+ CD206− macrophages was serine/threonine/tyrosine interacting like 1 (styxl1), a gene of largely uncharacterised function (HGNC: HUGO Gene Nomenclature Committee), followed closely by Versican (vcan), which is enriched in inflamed tissues containing leukocytic infiltrate, including IBD intestinal mucosa33,34. The gene discussed is FCGR1A; the disease is inflammatory bowel disease.