Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP), a type of histidine phosphatase protein, has been proven as a tumor suppressor in hepatocellular carcinoma [15] (HCC), cervical [16], pancreatic [17], bladder [18], and thyroid cancers [19] by regulating the AKT signaling pathway. The gene discussed is PHPT1; the disease is hepatocellular carcinoma.