Most tauopathies are sporadic, but a number of inherited mutations within the MAPT (microtubule-associated protein tau) gene encoding tau induce early onset neurodegeneration classified within frontotemporal lobar dementias (FTLD-tau; Hutton et al., 1998; Ghetti et al., 2015; Forrest et al., 2018). Here, MAPT is linked to tauopathy.