Notably, combined inhibition of sEH and EP4 stimulated RAW 264.7 or hMDM phagocytosis of gemcitabine-generated Hepa 1-6 or HepG2 tumor cell debris, respectively, to a greater extent than the sEH inhibitors or EP4 antagonists alone (Fig. 3 A and B). Here, EPHX2 is linked to neoplasm.