Chemokines and chemokine receptors are implicated in the mobilization and localization of immune cells to peripheral tissues and the generation of memory response.21–23 While a role for CXCR6 in CD8+ T cell resident memory responses has been reported in infectious disease models,24–26 there are no studies that directly address if specific chemokine receptors facilitate resident memory response by driving localization or retention of CD8+ T cells in cancerous tissues. This evidence concerns the gene CD8A and infectious disease.