In vitro studies show agglutination of platelets with lowering of Hb,29 30 others found an association between iron deficiency anaemia and thrombocytosis,31 32 and yet others suggest that anaemia impairs the role of red blood cells that normally push the platelets towards the vessel wall during the coagulation process to initiate clot formation.27 33. The gene discussed is GSTM1; the disease is anemia (phenotype).