KRAS and non-small cell lung carcinoma: In June 2021, the FDA awarded breakthrough therapy designation to adagrasib for KRAS-G12C–mutated NSCLC based on an unpublished phase I/II study showing that 45% (23/51) of participants responded and 51% (26/51) of them were in stable conditions after using adagrasib (600 mg/kg, twice daily).