The EMBRACE-HF trial showed that in patients with NYHA class III-IV HF and CardioMEMS pulmonary artery pressure sensors (mean pulmonary artery diastolic pressure 22 mmHg, median NT-pro-BNP 637 pg/mL), empagliflozin decreased pulmonary artery pressures independent of loop diuretic therapy [36]. The gene discussed is NPPB; the disease is hydrops fetalis.