Several major clinical cardiovascular outcome trials, such as the EMPA-REG outcome trial [2], CANVAS trial [20], DECLARE-TIMI 58 trial [21], and VERTIS-CV trial [22] have all shown that SGLT2 inhibitors can significantly reduce the risk of cardiovascular complications, cardiovascular mortality and heart failure hospitalizations in T2DM patients. Here, SLC5A2 is linked to type 2 diabetes mellitus.