MAPT and Alzheimer disease: Many factors, such as loss of acetylcholine (ACh)3,4, aggregation of Aβ5, hyperphosphorylation of tau protein6, disturbance of biometallic homeostasis7, oxidative stress8, neuroinflammation, and activation of microglia cells9, are all considered to play a pivotal role in the pathogenesis of AD and possess complicated interconnections.